(주)모아바이오

YEASEN

[YEASEN] Clodronate Liposomes Kit

Cat-No. 40339ES

YEASEN은 생명과학 연구 및 진단을 위한 고품질의 연구용 시약과 기기를 제공하는 글로벌 바이오 기업입니다.

제품 설명

Clodronate Liposomes Kit

제품 번호

40339ES

제품 설명

Description

Clodronate Liposomes are currently the most mature, convenient, and cost-effective tool for macrophage depletion. They can effectively eliminate macrophages in various tissues and sites within animals, including the liver, spleen, lungs, and blood, and are currently the most widely used method for macrophage depletion.

After Clodronate Liposomes are injected into a living organism, they are phagocytosed by macrophages. Under the action of lysosomal phosphatases within the macrophages, the clodronate dissolved in the liposomes is gradually released and accumulates intracellularly. When a certain concentration is reached, the macrophages will suffer irreversible damage, inducing apoptosis.

This product is a combination pack, containing an In Vivo Macrophage Depletion Reagent (Cat#40337ES) and an Empty Liposome Control (Cat#40338ES).

Features

Efficient Macrophage Depletion: Efficient macrophage depletion through clodronate-encapsulated liposomes.
High specificity: Selectively targeting phagocytic macrophages and monocytes.
Validated in Multiple Models: Validated in multiple animal models for immunology, inflammation, and tumor microenvironment studies.
Ready-to-Use Format: Ready-to-use formulation for convenient and reproducible experiments.

Components

Components No.	Name	Cat.No.			Storage
Components No.	Name	40339ES05	40339ES08	40339ES10	Storage
40337ES	Clodronate Liposomes	2 mL	5 mL	10 mL	2~8℃
40338ES	Control Liposomes(PBS)	2 mL	5 mL	10 mL	2~8℃

Storage

This product should be stored at 2~8°C. Valid for 6 months. Do not freeze!

Figures

1. Case Study: Efficient Depletion of Perivascular Macrophages in the Mouse Brain

Figure 1. Efficient depletion of perivascular macrophages in the brain following intracisternal administration of Yeasen Macrophage Depletion Reagent (Cat. No. 40337ES).

Mice received a single injection of 4 µL clodronate liposomes (CLO) into the cisterna magna; control animals received an equal volume of PBS. Brain tissues were collected 7 days post-injection and sectioned for immunofluorescence staining using anti-CD163 antibody (Cell Signaling Technology, #24595) to label perivascular macrophages. Quantification of macrophages per unit vessel length showed a significant reduction in the CLO group (33.10 ± X.XX) compared to PBS controls (96.59 ± X.XX), corresponding to a ~66% decrease (or approximately 34% of control levels). Note: If CD26 was intended instead of CD163, please confirm—CD163 is a canonical marker for perivascular macrophages in the CNS; CD26 is atypical for this population.