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YEASEN

[YEASEN] Clodronate Liposomes(From Vrije Universiteit Amsterdam)

Cat-No. 40337ES
40337ES08 / size: 5ml
40337ES10 / size: 10ml

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Clodronate Liposomes(From Vrije Universiteit Amsterdam)




제품 번호


40337ES08 / size: 5ml

40337ES10 / size: 10ml

 



제품 설명


Product Description

Clodronate Liposomes utilize the endocytosis mechanism of macrophages to carry membrane-impermeable clodronate (clodronate) into the cell. In the presence of macrophage lysosomal phosphatase, clodronate dissolved in the aqueous phase of liposomes is released and accumulates inside the cell. When it reaches a certain concentration it can induce the macrophage to enter the apoptotic process, thus functioning as a macrophage scavenger. 


Product Applications

Macrophages depletion

Clodronate Liposomes are suitable for a variety of injection methods, such as intravenous, intraperitoneal, subcutaneous, intranasal and testicular. The injection volume is related to the body weight of the mice, the injection cycle, the injection method and the purpose of the experiment.


Specifications

Solution

10 mM Na2HPO4,10 mM NaH2PO4,140 mM NaCl

Concentration

5 mg/mL

Lipid composition

Phosphatidylcholine and cholesterol


Shipping and Storage

The product is stored at 4. Transported in ice packs. Cannot be frozen! Shelf life 6 months.


Citations & References:

[1] Xiong X, Chen S, Shen J, et al. Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2. Signal Transduct Target Ther. 2022;7(1):99. Published 2022 Apr 6. doi:10.1038/s41392-022-00918-y(IF:18.187)

[2] Zhang Z, Chen C, Yang F, et al. Itaconate is a lysosomal inducer that promotes antibacterial innate immunity [published online ahead of print, 2022 May 25]. Mol Cell. 2022;S1097-2765(22)00443-9. doi:10.1016/j.molcel.2022.05.009(IF:17.970)

[3] Cai J, Peng J, Zang X, et al. Mammary Leukocyte-Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery [published online ahead of print, 2022 Jun 30]. Adv Sci (Weinh). 2022;e2200841. doi:10.1002/advs.202200841(IF:17.521)

[4] Jin H, Liu K, Tang J, et al. Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Nat Commun. 2021;12(1):2863. Published 2021 May 17. doi:10.1038/s41467-021-23197-7(IF:14.919)

[5] Sheng D, Ma W, Zhang R, et al. Ccl3 enhances docetaxel chemosensitivity in breast cancer by triggering proinflammatory macrophage polarization [published correction appears in J Immunother Cancer. 2022 Jun;10(6):]. J Immunother Cancer. 2022;10(5):e003793. doi:10.1136/jitc-2021-003793(IF:13.751)

[6] Zhao L, Zhang H, Liu X, et al. TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization. Acta Pharm Sin B. 2022;12(2):787-800. doi:10.1016/j.apsb.2021.07.011(IF:11.614)

[7] Xia L, Zhang C, Lv N, et al. AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages. Theranostics. 2022;12(6):2928-2947. Published 2022 Mar 21. doi:10.7150/thno.69533(IF:11.556)

[8] Zhang X, Hou L, Li F, et al. Piezo1-mediated mechanosensation in bone marrow macrophages promotes vascular niche regeneration after irradiation injury. Theranostics. 2022;12(4):1621-1638. Published 2022 Jan 16. doi:10.7150/thno.64963(IF:11.556)

[9] Wang H, Li L, Li Y, et al. Intravital imaging of interactions between iNKT and kupffer cells to clear free lipids during steatohepatitis. Theranostics. 2021;11(5):2149-2169. Published 2021 Jan 1. doi:10.7150/thno.51369(IF:11.556)

[10] Xun J, Du L, Gao R, et al. Cancer-derived exosomal miR-138-5p modulates polarization of tumor-associated macrophages through inhibition of KDM6B. Theranostics. 2021;11(14):6847-6859. Published 2021 May 3. doi:10.7150/thno.51864(IF:11.556)

[11] Zuo L, Li J, Zhang X, et al. Aberrant mesenteric adipose extracellular matrix remodeling is involved in adipocyte dysfunction in Crohn's disease: The role of TLR-4-mediated macrophages [published online ahead of print, 2022 Jun 16]. J Crohns Colitis. 2022;jjac087. doi:10.1093/ecco-jcc/jjac087(IF:9.071)

[12] Huang C, Wang J, Liu H, et al. Ketone body β-hydroxybutyrate ameliorates colitis by promoting M2 macrophage polarization through the STAT6-dependent signaling pathway. BMC Med. 2022;20(1):148. Published 2022 Apr 15. doi:10.1186/s12916-022-02352-x(IF:8.775)

[13] Jiang P, Gao W, Ma T, et al. CD137 promotes bone metastasis of breast cancer by enhancing the migration and osteoclast differentiation of monocytes/macrophages. Theranostics. 2019;9(10):2950-2966. Published 2019 May 9. doi:10.7150/thno.29617(IF:8.063)

[14] Yang XL, Wang G, Xie JY, et al. The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon. mBio. 2021;12(3):e00366-21. Published 2021 May 11. doi:10.1128/mBio.00366-21(IF:7.867)

[15] Sun Z, Huang W, Zheng Y, et al. Fpr2/CXCL1/2 Controls Rapid Neutrophil Infiltration to Inhibit Streptococcus agalactiae Infection. Front Immunol. 2021;12:786602. Published 2021 Nov 24. doi:10.3389/fimmu.2021.786602(IF:7.561)

[16] Cai J, Cui X, Wang X, You L, Ji C, Cao Y. A Novel Anti-Infective Peptide BCCY-1 With Immunomodulatory Activities. Front Immunol. 2021;12:713960. Published 2021 Jul 22. doi:10.3389/fimmu.2021.713960(IF:7.561)




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